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Related Experiment Videos

Hypoxic ventilatory response decreases during sleep in normal men

N J Douglas, D P White, J V Weil

    The American Review of Respiratory Disease
    |March 1, 1982
    PubMed
    Summary

    The hypoxic ventilatory response (HVR) significantly decreases during sleep, especially during REM sleep. This reduction in HVR may contribute to sleep-related hypoxemia in various conditions.

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    Area of Science:

    • Sleep Medicine
    • Respiratory Physiology

    Background:

    • Ventilatory drives are crucial for maintaining breathing during sleep.
    • While the hypercapnic ventilatory response decreases in sleep, the hypoxic ventilatory response (HVR) in humans remains less understood.

    Purpose of the Study:

    • To quantify the hypoxic ventilatory response (HVR) in sleeping men.
    • To compare HVR during wakefulness, non-REM sleep, and REM sleep.

    Main Methods:

    • Measured the ventilatory response to isocapnic hypoxia in 6 sleeping men.
    • Quantified HVR as the slope of ventilation versus decreasing hemoglobin oxygen saturation.

    Main Results:

    • HVR was significantly lower in all sleep stages compared to wakefulness.

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  • HVR in non-REM sleep was two-thirds of the waking value.
  • HVR in REM sleep was less than one-third of the waking value.

    • Conclusions:

    • The hypoxic ventilatory response is significantly blunted during both non-REM and REM sleep.
    • Reduced HVR during REM sleep may explain REM-sleep-related hypoxemia in healthy individuals and patients with cardiovascular diseases.