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Published on: November 6, 2020
Candidal suppurative peripheral thrombophlebitis
Annals of Internal Medicine
|April 1, 1982
Summary
Persistent candidemia from suppurative peripheral thrombophlebitis is a serious complication of intravenous therapy. Surgical vein excision and antifungal treatment effectively cured five patients with this rare Candida infection.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Vascular Surgery
Background:
- Transient candidemia is frequent during prolonged intravenous therapy.
- Sustained candidemia often signifies a persistent infection source.
- Candidal suppurative peripheral thrombophlebitis is an underrecognized complication of intravenous therapy.
Observation:
- Six cases of candidemia associated with thrombosed peripheral veins at intravenous sites were identified.
- Infections presented as Candida septicemia, with or without disseminated candidiasis.
- Surgical exploration revealed suppurative thrombosed veins with positive Candida cultures.
Findings:
- Candida was detected in the luminal clot and vascular wall via special stains.
- Five of six patients achieved cure through surgical excision of the affected vein.
- Antifungal therapy, including amphotericin B and 5-fluorocytosine, was administered to some survivors.
Implications:
- Highlights candidal suppurative peripheral thrombophlebitis as a distinct clinical entity.
- Emphasizes the importance of surgical intervention for managing this complication.
- Suggests a combined approach of surgery and antifungal agents for optimal patient outcomes.
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