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Related Experiment Videos

0.1% triamcinolone acetonide ointment and patch test responses

R A Clark, R L Rietschel

    Archives of Dermatology
    |March 1, 1982
    PubMed
    Summary
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    Topical steroids, like triamcinolone acetonide, minimally affect patch test results for contact allergy detection. These findings suggest that prior steroid use is unlikely to interfere with diagnosing allergies via patch testing.

    Area of Science:

    • Dermatology
    • Allergology
    • Pharmacology

    Background:

    • Patch testing is a crucial diagnostic tool for identifying contact allergies.
    • The potential influence of topical corticosteroids on patch test reactivity requires clarification.

    Purpose of the Study:

    • To investigate the impact of a commonly used topical steroid, triamcinolone acetonide, on the responsiveness of patch tests.

    Main Methods:

    • 15 subjects underwent patch testing on opposing arm sites.
    • One site received 0.1% triamcinolone acetonide ointment, while the other received a control preparation, applied thrice daily before testing.

    Main Results:

    • Substantial differences in patch test reactions were observed in only 3 out of 18 paired tests after 96 hours.

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  • Most reactions were comparable between steroid-treated and control sites, with minor variations in intensity in a few cases.

    • Conclusions:

    • Intermediate-strength topical steroids are unlikely to significantly suppress patch test responsiveness.
    • The use of topical steroids prior to patch testing is unlikely to prevent the accurate detection of contact allergies.