[Oxidative phosphorylation during functional changes]

Under changes of the physiological state of rats and mice phosphorylating (mitochondria) and free (presumably microsomal) oxidation was investigated as an amythal-sensitive portion of total oxygen consumption in the animals. Five types of the functional states were obtained with the use of muscle work as training or overloading factor, emotional stress and muscle work in the hypoxic environment : (1) optimal (training), (2) normal, (3) prepathology, (4) pathology, (5) prelethal. Phosphorylating oxidation was shown to be the most sensitive portion of the total body respiration. It moderately decreased in the optimal state and progressively rose under pathology. Free oxidation did not change within the range of states 1-3 and decreased under pathology the more the higher phosphorylating oxidation. Restriction of phosphorylating oxidation revealed in the trained animals allows one to explain the phenomenon of oxygen consumption saving by the trained body. In sports physiology, the phenomenon in question is known to be due to the most effective function of the respiratory chain of mitochondria.