Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chronic phencyclidine, like amphetamine, produces a decrease in [3H]spiroperidol binding in rat striatum

H A Robertson

    European Journal of Pharmacology
    |March 12, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Early alterations of functional connectivity, regional brain volumes and astrocyte markers in the beta-sitosterol beta-d-glucoside (BSSG) rat model of parkinsonism.

    Experimental neurology·2024
    Same author

    A new experimental model for the investigation of sequential hermaphroditism.

    Scientific reports·2021
    Same author

    Lateralized microstructural changes in early-stage Parkinson's disease in anterior olfactory structures, but not in substantia nigra.

    Journal of neurology·2017
    Same author

    Antisense Therapeutics in the Central Nervous System : The Induction of c-fos.

    Methods in molecular medicine·2011
    Same author

    Expression of the inhibitor of apoptosis protein family in multiple sclerosis reveals a potential immunomodulatory role during autoimmune mediated demyelination.

    Multiple sclerosis (Houndmills, Basingstoke, England)·2008
    Same author

    A possible role for dopamine D3 receptor stimulation in the induction of neurogenesis in the adult rat substantia nigra.

    Neuroscience·2005
    Same journal

    Astaxanthin inhibits platelet-mediated thrombosis via suppression of bidirectional αIIbβ3 signaling.

    European journal of pharmacology·2026
    Same journal

    Repurposing of alogliptin to mitigate experimentally-induced ulcerative colitis and its associated pulmonary injury in rats through regulating inflammatory, necroptotic, and ER stress pathways.

    European journal of pharmacology·2026
    Same journal

    Erianin ameliorates liver fibrosis through the PRDX3/NLRX1 axis.

    European journal of pharmacology·2026
    Same journal

    4-Octyl itaconate attenuates renal calculi formation by inhibiting ferroptosis and oxidative stress via the Nrf2-HO-1/SLC7A11 axis.

    European journal of pharmacology·2026
    Same journal

    VER155008 rescues cognitive impairment in P301S tauopathy mice by promoting HSPA8-mediated lipophagy.

    European journal of pharmacology·2026
    Same journal

    Okanin alleviates osteoarthritis by suppressing oxidative stress and pyroptosis via Nrf2/HO-1 activation.

    European journal of pharmacology·2026
    See all related articles

    Chronic treatment with amphetamine and phencyclidine (PCP) in rats reduced dopamine receptor numbers in the striatum. This suggests PCP

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Psychiatry

    Background:

    • Dopamine receptors are crucial for neurotransmission.
    • Phencyclidine (PCP) is known to induce psychosis-like symptoms.
    • Amphetamine also affects dopamine systems and can cause psychosis.

    Purpose of the Study:

    • To investigate the effects of chronic d-amphetamine sulfate and phencyclidine (PCP) administration on dopamine receptors in rat striatum.
    • To determine if PCP's psychotic effects involve alterations in dopamine receptor binding.

    Main Methods:

    • Rats were administered d-amphetamine sulfate (5 and 10 mg/kg) or phencyclidine (PCP) (5 mg/kg) intraperitoneally twice daily for 21 days.
    • Following treatment, [3H]spiroperidol binding assays were performed on striatal tissue.

    Related Experiment Videos

  • Analysis focused on changes in receptor number (Bmax) and affinity (KD).

    • Main Results:

    • All treatments, including d-amphetamine and PCP, significantly reduced [3H]spiroperidol binding in the striatum.
    • The reduction in binding was attributed to a decrease in the number of dopamine receptors (Bmax), not a change in their binding affinity (KD).

    Conclusions:

    • Chronic administration of both d-amphetamine and PCP alters dopamine receptor characteristics in the rat striatum.
    • The findings support the hypothesis that PCP's psychotomimetic effects may be mediated by changes in dopamine receptor regulation, similar to amphetamine.