Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Escapability and generalization: effect on 'behavioral despair'

K A O'Neill, D Valentino

    European Journal of Pharmacology
    |March 12, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    High-yield isolation and characterization of microvascular niche cells from human full-thickness skin biopsies.

    Scientific reports·2026
    Same author

    SU-E-I-60: Validation of An Optically Stimulated Luminescent (OSL) Dosimeter for Use in Output Exposure Control Verification of Mammography Imaging Systems.

    Medical physics·2017
    Same author

    Case-control study of paternal occupation and social class with risk of childhood central nervous system tumours in Great Britain, 1962-2006.

    British journal of cancer·2013
    Same author

    Case-control study of paternal occupation and childhood leukaemia in Great Britain, 1962-2006.

    British journal of cancer·2012
    Same author

    The ITS region as a taxonomic discriminator between Fusarium verticillioides and Fusarium proliferatum.

    Mycological research·2009
    Same author

    Update on digital image management and PACS.

    Abdominal imaging·2000
    Same journal

    Astaxanthin inhibits platelet-mediated thrombosis via suppression of bidirectional αIIbβ3 signaling.

    European journal of pharmacology·2026
    Same journal

    Repurposing of alogliptin to mitigate experimentally-induced ulcerative colitis and its associated pulmonary injury in rats through regulating inflammatory, necroptotic, and ER stress pathways.

    European journal of pharmacology·2026
    Same journal

    Erianin ameliorates liver fibrosis through the PRDX3/NLRX1 axis.

    European journal of pharmacology·2026
    Same journal

    4-Octyl itaconate attenuates renal calculi formation by inhibiting ferroptosis and oxidative stress via the Nrf2-HO-1/SLC7A11 axis.

    European journal of pharmacology·2026
    Same journal

    VER155008 rescues cognitive impairment in P301S tauopathy mice by promoting HSPA8-mediated lipophagy.

    European journal of pharmacology·2026
    Same journal

    Okanin alleviates osteoarthritis by suppressing oxidative stress and pyroptosis via Nrf2/HO-1 activation.

    European journal of pharmacology·2026
    See all related articles

    Rats display behavioral despair regardless of task difficulty. This behavioral despair does not transfer to a different type of escape task, questioning the model's broad applicability.

    Area of Science:

    • Neuroscience
    • Animal Behavior

    Background:

    • The 'behavioral despair' test is a common model for studying depression-like behaviors in rodents.
    • Understanding the specific conditions that elicit and generalize this response is crucial for its accurate interpretation.

    Purpose of the Study:

    • To determine if 'behavioral despair' in rats is contingent on the inescapability of a warm swim.
    • To assess whether 'behavioral despair' observed in the warm swim test generalizes to a distinct shock escape task.

    Main Methods:

    • Two experiments were conducted using rodent models.
    • Experiment 1: Assessed behavioral despair in rats exposed to a warm swim with varying degrees of escapability.
    • Experiment 2: Examined if behavioral despair generalized to a shock escape task.

    Related Experiment Videos

    Main Results:

    • Rats exhibited 'behavioral despair' irrespective of whether the warm swim was escapable or not.
    • The 'behavioral despair' phenomenon did not generalize to the shock escape task.

    Conclusions:

    • The 'behavioral despair' response appears independent of the specific condition of inescapability in the warm swim test.
    • Findings raise questions about the generalizability and validity of the behavioral despair model for all stress-related conditions.