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Immunologic status in severe obesity

D N McMurray, P A Beskitt, S R Newmark

    International Journal of Obesity
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Severe obesity without complications does not significantly impair immune function. Studies found normal immunoglobulin levels, secretory IgA, and lymphocyte responses in obese adults, suggesting overweight alone doesn't cause immune dysfunction.

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    Area of Science:

    • Immunology
    • Obesity Research
    • Clinical Investigation

    Background:

    • Obesity is a growing public health concern.
    • The impact of severe obesity on immune status is not fully understood.
    • Previous research suggests potential immune alterations in obesity.

    Purpose of the Study:

    • To investigate humoral, secretory, and cell-mediated immunity in severe, uncomplicated obesity.
    • To determine if severe overweight alone, independent of diabetes or hyperlipidemia, affects immune function.
    • To compare immune parameters in obese adults with normal-weight controls.

    Main Methods:

    • Assessed serum immunoglobulin (IgG, IgA, IgM, IgD) and complement (C3, C4) levels.
    • Measured tear secretory IgA and lysozyme.

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  • Evaluated T and B lymphocyte subpopulations.
  • Assessed in vitro lymphocyte response to mitogens and in vivo skin test reactivity.

    • Main Results:

    • Obese adults exhibited normal serum immunoglobulin and complement concentrations.
    • Tear secretory IgA and lysozyme levels were comparable to controls.
    • Lymphocyte subpopulations and responses to mitogens were similar to controls.
    • Most obese patients demonstrated normal skin test reactivity to recall antigens.

    Conclusions:

    • Severe obesity, when uncomplicated by other metabolic diseases, is not associated with significant immune system dysfunction.
    • Humoral, secretory, and cell-mediated immunity appear preserved in individuals with severe overweight.
    • These findings suggest that obesity-related immune alterations may be linked to comorbid conditions rather than overweight itself.