Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Framework invasion by laryngeal carcinomas

M R Pittam, R L Carter

    Head & Neck Surgery
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Detecting laryngeal cancer invasion is challenging. Ear pain and laryngeal tomograms show promise, but direct laryngoscopy often underdiagnoses transglottic tumors and infraglottic extension.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Structural changes in membranes of synchronized cells demonstrated by freeze-cleavage.

    Nature: New biology·2010
    Same author

    Effect of teenage pregnancy on educational disabilities in kindergarten.

    American journal of epidemiology·2001
    Same author

    Effect of pollution on genetic diversity in the bay mussel Mytilus galloprovincialis and the acorn barnacle Balanus glandula.

    Marine environmental research·2001
    Same author

    The outcome in the United States after thoracoabdominal aortic aneurysm repair, renal artery bypass, and mesenteric revascularization.

    Journal of vascular surgery·2001
    Same author

    Extragenic suppressors of the nimX2(cdc2) mutation of Aspergillus nidulans affect nuclear division, septation and conidiation.

    Genetics·2000
    Same author

    Raman spectra of the double-anion salts M3ZnCl4NO3 (M+ = K+, Rb+, NH4).

    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2000
    Same journal

    Ethical dilemmas in head and neck cancer.

    Head & neck surgery·1989
    Same journal

    Nasal septal melanoma.

    Head & neck surgery·1988
    Same journal

    Malignant oncocytoma of the maxillary sinus--an ultrastructural study.

    Head & neck surgery·1988
    Same journal

    Adult parapharyngeal extracardiac rhabdomyoma.

    Head & neck surgery·1988
    Same journal

    Retropharyngeal infiltrating lipoma--a case report.

    Head & neck surgery·1988
    Same journal

    Lymphoma presenting as a salivary gland mass.

    Head & neck surgery·1988
    See all related articles

    Area of Science:

    • Oncology
    • Otolaryngology
    • Radiology

    Background:

    • Accurate detection of laryngeal cancer invasion is crucial for effective treatment planning.
    • Standard clinical and radiologic methods have limitations in identifying laryngeal framework invasion and transglottic tumors.

    Purpose of the Study:

    • To evaluate the accuracy of clinical and radiologic methods in detecting laryngeal framework invasion and transglottic tumors.
    • To correlate findings with pathological outcomes in squamous cell carcinoma of the larynx.

    Main Methods:

    • Retrospective analysis of 50 laryngectomy cases for squamous cell carcinoma.
    • Comparison of clinical, radiologic (laryngeal tomograms), and pathological findings.
    • Correlation of tumor size, framework invasion, and treatment history (including radiation therapy).

    Related Experiment Videos

    Main Results:

    • Ear pain before laryngectomy indicated laryngeal framework or extralaryngeal soft tissue spread in 11 of 12 patients.
    • Laryngeal tomograms correctly identified 10 of 14 transglottic tumors but had a high false-positive rate.
    • Direct laryngoscopy significantly underdiagnosed transglottic tumors and infraglottic extension.
    • Framework invasion was associated with transglottic tumors ≥ 2 cm in diameter.
    • Patients with framework invasion showed a significantly higher rate of early recurrence and cervical node metastasis.

    Conclusions:

    • Clinical symptoms like ear pain and advanced imaging like laryngeal tomograms can aid in detecting laryngeal cancer invasion.
    • Direct laryngoscopy is insufficient for diagnosing transglottic tumors and infraglottic extension.
    • Laryngeal framework invasion is a critical prognostic factor associated with poorer outcomes and increased recurrence risk.