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Urate nephrolithiasis in ranch mink

M J Tomlinson, V Perman, R L Westlake

    Journal of the American Veterinary Medical Association
    |March 15, 1982
    PubMed
    Summary
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    An inherited defect caused urate nephrolithiasis, epistaxis, and bleeding in ranch mink. Eliminating affected animals and related sires from breeding programs resolved the condition, suggesting a genetic link to uric acid metabolism.

    Area of Science:

    • Veterinary Pathology
    • Genetics
    • Metabolic Disorders

    Background:

    • Urate nephrolithiasis, epistaxis, and bleeding around foot pads were observed in ranch mink.
    • Previous investigations did not identify the specific cause of these clinical signs.

    Observation:

    • Affected mink were exclusively male, sired by related males, and presented with symptoms within their first year.
    • Eliminating affected mink and their parents from the breeding stock successfully eradicated the condition from the herd.

    Findings:

    • The study ruled out inherited bleeding disorders as the cause of bleeding.
    • The observed pattern strongly suggests an inherited defect in uric acid metabolism or excretion.

    Implications:

    Related Experiment Videos

  • This research highlights a potential genetic predisposition to urate nephrolithiasis and associated bleeding in ranch mink.
  • Management strategies involving selective breeding and culling can effectively control this inherited condition.