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Related Experiment Videos

Circulating thymic-hormone activity in congenital immunodeficiency

V Lewis, J J Twomey, G Goldstein

    Lancet (London, England)
    |September 3, 1977
    PubMed
    Summary

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    Circulating thymic-hormone activity, measured by Thy 1-2 antigen induction, was low in infants with immune deficiencies. Successful immune reconstitution therapies led to increased thymic-hormone levels.

    Area of Science:

    • Immunology
    • Endocrinology
    • Pediatrics

    Background:

    • Thymic hormones are crucial for T-cell development.
    • Assessing circulating thymic-hormone activity can indicate immune system health.

    Purpose of the Study:

    • To measure circulating thymic-hormone activity in children.
    • To correlate thymic-hormone levels with immune status and treatment outcomes.

    Main Methods:

    • Assaying thymic-hormone activity by measuring Thy 1-2 antigen induction on lymphocytes from athymic mice.
    • Incubating lymphocytes with human plasma or serum from normal children and infants with immune deficiencies.

    Main Results:

    • Normal children under 10 showed significant thymic-hormone activity.

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  • Infants with severe combined immunodeficiency and DiGeorge syndrome exhibited little to no activity.
  • Successful immune reconstitution therapies (thymus/bone-marrow grafts, specific red-cell infusions) correlated with increased thymic-hormone activity.

    • Conclusions:

    • Circulating thymic-hormone activity is a potential biomarker for immune function in children.
    • Therapeutic interventions for immune deficiencies can restore thymic-hormone levels.