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Sterile Pericarditis in Aachener Minipigs As a Model for Atrial Myopathy and Atrial Fibrillation
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Natural history of high-grade atrioventricular block following permanent pacemaker implantation

M A Alpert, S K Katti

    Journal of Chronic Diseases
    |January 1, 1982
    PubMed

    Insights

    Permanent pacemaker implantation for high-grade atrioventricular block shows lower survival with congestive heart failure or coronary heart disease. These conditions significantly impact long-term outcomes in patients with pacemakers.

    Area of Science:

    • Cardiology
    • Medical Devices
    • Clinical Outcomes

    Background:

    • High-grade atrioventricular block necessitates permanent pacemaker implantation.
    • Long-term survival post-pacemaker implantation is influenced by various factors.
    • Understanding these factors is crucial for patient management and prognosis.

    Purpose of the Study:

    • To evaluate the impact of sex, age, implantation date, and comorbidities on survival after permanent pacemaker implantation for high-grade atrioventricular block.
    • To identify key determinants of long-term survival in this patient population.

    Main Methods:

    • A cohort of 120 patients implanted with permanent pacemakers for high-grade atrioventricular block were followed for 4-14 years.
    • Survival rates were analyzed based on demographic factors and the presence of chronic co-existent illnesses.

    Main Results:

    • Overall survival rates were 91% at 1 year, 63% at 5 years, and 41% at 10 years.
    • Congestive heart failure and coronary heart disease were associated with significantly lower survival rates.
    • Hypertension, valvular heart disease, diabetes mellitus, and cerebral infarction had less adverse effects on survival compared to CHF and CHD.

    Conclusions:

    • Congestive heart failure and coronary heart disease are major determinants of survival in patients with permanent pacemakers for high-grade atrioventricular block.
    • Sex and date of implantation did not significantly affect survival.
    • Age at implantation showed a trend towards decreased survival with increasing age, but this was not statistically significant.

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