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Related Experiment Video

Updated: Jul 6, 2026

Overcoming Unresponsiveness in Experimental Autoimmune Encephalomyelitis (EAE) Resistant Mouse Strains by Adoptive Transfer and Antigenic Challenge

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Published on: April 9, 2012

Long-lasting, specific immunologic unresponsiveness associated with cryptococcal meningitis

D K Henderson, J E Bennett, M A Huber

The Journal of Clinical Investigation

|May 1, 1982

Summary

Patients cured of cryptococcal meningitis show prolonged immunologic unresponsiveness to cryptococcal capsular polysaccharide (CPS) immunization. This impaired response suggests a need for further research into immune function after cryptococcosis recovery.

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Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Published on: November 5, 2019

Area of Science:

Immunology
Infectious Diseases
Vaccinology

Background:

Cryptococcosis is a serious fungal infection, particularly cryptococcal meningitis.
Immune responses to polysaccharide antigens are crucial for protection against encapsulated pathogens.
Understanding immune function post-cryptococcosis is vital for patient management and vaccine development.

Purpose of the Study:

To assess the immune response in patients cured of cryptococcosis after immunization with cryptococcal capsular polysaccharide (CPS) and type III pneumococcal polysaccharide.
To compare the antibody responses between cured patients and healthy controls.

Main Methods:

Radioimmunoassay (RIA) and antibody class-specific enzyme-linked immunosorbent assay (ELISA) were employed.
10 healthy volunteers and 8 patients cured of cryptococcal meningitis were immunized with CPS and type III pneumococcal polysaccharide.
Antibody titers (IgA, IgM, IgG) were measured before and after immunization.

Main Results:

Patients exhibited significantly lower geometric mean titers to CPS post-immunization compared to controls (1:3 vs. 1:119, P < 0.01).
Specific antibody class analysis revealed minimal IgG and IgA anti-CPS responses in patients.
Postvaccination IgM titers against CPS were markedly reduced in patients (1:31) versus controls (1:238, P < 0.01).
Responses to type III pneumococcal polysaccharide were comparable between patients and controls across all antibody classes (P > 0.2).

Conclusions:

Cured cryptococcal meningitis is frequently associated with a prolonged, specific immunologic unresponsiveness.
The impaired response to CPS, but not pneumococcal polysaccharide, suggests a specific defect in B-cell memory or function following cryptococcosis.
Further investigation is warranted to elucidate the mechanisms underlying this specific immunologic deficit.