Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunoglobulin-containing cells in multiple-sclerosis plaques

M M Esiri

    Lancet (London, England)
    |September 3, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Neuropathological Evidence of Reduced Amyloid Beta and Neurofibrillary Tangles in Multiple Sclerosis Cortex.

    Annals of neurology·2025
    Same author

    Neuropathology of the hippocampus in FTLD-Tau with Pick bodies: a study of the BrainNet Europe Consortium.

    Neuropathology and applied neurobiology·2012
    Same author

    Neuropathologic evidence of endothelial changes in cerebral small vessel disease.

    Neurology·2011
    Same author

    Focal and diffuse cortical degenerative changes in a marmoset model of multiple sclerosis.

    Multiple sclerosis (Houndmills, Basingstoke, England)·2010
    Same author

    MS: is it one disease?

    International MS journal·2009
    Same author

    Loss of [3H]4-DAMP binding to muscarinic receptors in the orbitofrontal cortex of Alzheimer's disease patients with psychosis.

    Psychopharmacology·2008
    Same journal

    Medical compartmentalisation: a patient with chromosome 22q11.2 deletion syndrome in Japan.

    Lancet (London, England)·2026
    Same journal

    [<sup>177</sup>Lu]Lu-edotreotide versus everolimus for gastroenteropancreatic neuroendocrine tumours (COMPETE): a phase 3, multicentre, randomised, open-label, superiority trial.

    Lancet (London, England)·2026
    Same journal

    Research priorities for characterising Bundibugyo virus.

    Lancet (London, England)·2026
    Same journal

    Rethinking treatment sequence in advanced gastroenteropancreatic neuroendocrine tumours.

    Lancet (London, England)·2026
    Same journal

    Dual mobility total hip replacement in fractures: stability promotes patient confidence.

    Lancet (London, England)·2026
    Same journal

    Dual mobility versus standard cups in total hip replacement for displaced femoral neck fractures (Duality): an international, multicentre, randomised, controlled, superiority trial.

    Lancet (London, England)·2026
    See all related articles

    Multiple sclerosis (M.S.) plaques show increased immunoglobulin-producing cells compared to normal tissue. These cells, predominantly producing IgG, suggest local immune responses within M.S. lesions.

    Area of Science:

    • Neuroimmunology
    • Pathology

    Background:

    • Multiple sclerosis (M.S.) is a chronic inflammatory demyelinating disease of the central nervous system.
    • The role of local immunoglobulin production within M.S. lesions remains an area of active investigation.

    Purpose of the Study:

    • To investigate the presence and characteristics of immunoglobulin-containing cells within multiple sclerosis plaques.
    • To compare immunoglobulin cell content in active versus chronic M.S. lesions and adjacent normal tissue.

    Main Methods:

    • Immunoperoxidase staining was employed to quantify immunoglobulin-containing cells.
    • Analysis was performed on post-mortem brain tissue from ten M.S. patients, comparing 100 plaques with 100 adjacent normal white matter areas.

    Main Results:

    Related Experiment Videos

    • Immunoglobulin-containing cells were significantly more abundant in M.S. plaques than in normal tissue.
    • Recent plaques exhibited a higher density of immunoglobulin cells compared to older plaques.
    • Cells within plaques showed a higher proportion of light chains and an elevated kappa/lambda ratio, particularly in recent lesions.
    • The predominant immunoglobulin heavy chain identified was IgG (92%), followed by IgA (7.3%) and IgM (0.7%).

    Conclusions:

    • M.S. plaques are associated with a localized proliferation of immunoglobulin-producing cells.
    • These cells predominantly produce IgG with kappa light chains, suggesting a restricted B-cell response within lesions.
    • The findings support the hypothesis of local immune activity contributing to the pathogenesis of multiple sclerosis.