Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Imipramine disposition in alcoholics

D A Ciraulo, L M Alderson, D J Chapron

    Journal of Clinical Psychopharmacology
    |February 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    HIV-Risk Behavior Among Adults with Opioid Use Disorder During 12 Months Following Pre-trial Detention: Results from a Randomized Trial of Methadone Treatment.

    AIDS and behavior·2020
    Same author

    Methadone treatment of arrestees: A randomized clinical trial.

    Drug and alcohol dependence·2019
    Same author

    Broadening of the Rotational Lines of Carbon Monoxide by HCl and by Argon.

    Journal of research of the National Bureau of Standards. Section A, Physics and chemistry·2019
    Same author

    Corrigendum to "A randomized trial of intensive outpatient (IOP) vs. standard outpatient (OP) buprenorphine treatment for African Americans" [Drug Alcohol Depend. 128 (2013) 222-229].

    Drug and alcohol dependence·2016
    Same author

    Epstein-Barr virus-positive multiple myeloma following an ABO incompatible second renal transplantation.

    Indian journal of nephrology·2016
    Same author

    Adult-onset congenital thrombotic thrombocytopenic purpura caused by a novel compound heterozygous mutation of the ADAMTS13 gene.

    International journal of hematology·2015

    Alcoholism significantly impacts imipramine (IMI) drug levels in depressed patients, leading to reduced effectiveness. Chronic ethanol intake may increase IMI clearance, affecting treatment outcomes.

    Area of Science:

    • Pharmacology
    • Psychiatry
    • Clinical Medicine

    Background:

    • Depression is a common comorbidity with alcoholism.
    • Imipramine (IMI) is a tricyclic antidepressant used to treat depression.
    • Understanding drug disposition in co-occurring conditions is crucial for effective treatment.

    Purpose of the Study:

    • To investigate the pharmacokinetic disposition of orally administered imipramine (IMI) in depressed alcoholic versus non-alcoholic male inpatients.
    • To compare plasma levels, clearance, and half-life of IMI and its metabolites between the two groups.
    • To assess the clinical efficacy of IMI in relieving depressive symptoms in both patient groups.

    Main Methods:

    • 11 depressed alcoholic and 12 depressed non-alcoholic male inpatients received imipramine (50 mg TID) for steady-state.

    Related Experiment Videos

  • Plasma samples were collected over 40 hours post-discontinuation.
  • Imipramine, desipramine, and 2-hydroxyimipramine levels were quantified using high-performance liquid chromatography (HPLC).

    • Main Results:

    • Alcoholic patients exhibited significantly lower plasma levels of imipramine (IMI) and 2-hydroxyimipramine eight hours after the last dose compared to controls.
    • The mean terminal half-lives of IMI were similar between alcoholics and non-alcoholics.
    • Imipramine therapy significantly reduced Beck Depression Inventory scores in non-alcoholics, but not in alcoholics.

    Conclusions:

    • Results suggest either decreased oral bioavailability or a 2.5-fold increase in intrinsic clearance of imipramine in alcoholics, likely due to chronic ethanol intake.
    • Lower IMI levels in alcoholics correlated with a lack of antidepressant efficacy.
    • Ethanol consumption is a critical factor influencing imipramine disposition and therapeutic outcomes in depressed patients.