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Related Experiment Videos

Sex difference in brain atrophy during aging; a quantitative study with computed tomography

J Hatazawa, M Ito, H Yamaura

    Journal of the American Geriatrics Society
    |April 1, 1982
    PubMed
    Summary

    Brain atrophy, measured by the Brain Volume Index (BVI), shows distinct age-related patterns in men and women. Significant brain volume loss begins earlier in women than in men, with individual variations present in both sexes.

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    Area of Science:

    • Neuroimaging
    • Gerontology
    • Quantitative Anatomy

    Background:

    • Brain atrophy is a natural part of aging.
    • Understanding sex-specific differences in brain volume changes is crucial for aging research.
    • Quantitative assessment of brain atrophy requires standardized metrics.

    Purpose of the Study:

    • To quantitatively assess brain atrophy in healthy adults across different age groups.
    • To investigate potential sex differences in the rate and onset of age-related brain atrophy.
    • To establish a reliable indicator for brain atrophy using computed tomography.

    Main Methods:

    • Computed tomography (CT) scans of 154 men and 147 women (ages 20-79) without neurological deficits.
    • Calculation of the Craniocerebral Index (CCI) as brain volume percentage within the cranial cavity.

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  • Development of the Brain Volume Index (BVI) to quantify atrophy relative to a standard non-atrophied brain volume.

    • Main Results:

    • A significant reduction in BVI began in the sixth decade for men and the fifth decade for women.
    • Women showed a significant decline starting in their fifth decade, stabilizing, then declining again in later decades.
    • Men exhibited a gradual, steady decline in BVI from the sixth decade onwards.
    • Remarkable individual variability in brain atrophy was observed in both sexes.

    Conclusions:

    • Age-related brain atrophy exhibits distinct sex-specific trajectories.
    • The Brain Volume Index (BVI) serves as a sensitive indicator for quantifying brain atrophy.
    • Further research is warranted to explore the clinical implications of these sex- and age-related differences in brain volume.