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A 3D System for Culturing Human Articular Chondrocytes in Synovial Fluid
09:58

A 3D System for Culturing Human Articular Chondrocytes in Synovial Fluid

Published on: January 31, 2012

The synovial cavity as a "tissue culture in situ"--science or nonsense?

A D Potenza, M C Herte

    The Journal of Hand Surgery
    |March 1, 1982
    PubMed

    Acellular freeze-dried canine profundus tendon allografts were placed in the knee joints of dogs and later harvested at 2, 3, and 6 weeks. All allografts remained intact, free swimming, and free of adhesions; all were covered by a layer of proliferating fibroblast-like cells that "healed" cuts made in the allografts, rounded off their previously squared-off ends, and recellularized them. The cell source for the phenomena was the synovial cell of the joint, a highly versatile, facultative fibroblast. An intrinsic capacity of flexor tendons to heal themselves cannot be critically tested by fallaciously considering synovial cavities "tissue cultures in situ," as some investigators have claimed.

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