[Studies on coagulation-fibrinolysis system and cold insoluble globulin in normal pregnancy (author's transl)]

Hypercoagulability and diminished fibrinolysis during pregnancy have been reported fragmentarily by several investigators. However, systemic informations of coagulation-fibrinolysis bared on the multifactorial and stage-dependent analyses have not appeared. The factors of coagulation (XII, IX, VIII, VII, X, XIII, prothrombin, platelet, fibrinogen), fibrinolytic enzyme system (euglobulin clot lysis time, eug . lysis area of SK (Std), plasminogen, SFMC, FDP), serin protease inhibitor in plasma (AT-III, C1-INA, alpha 2-PI, alpha 2-M, alpha 1-AT) and CIG were determined on 30 normal non-pregnant women as control, and total 270 normal gravidas. The activities of the intrinsic coagulation factors were markedly increased after middle stage of pregnancy with advance of gestational ages, while those of the extrinsic system increased slightly even in late stage of pregnancy. Factor XIII and C1-INA decreased, SFMC and FDP elevated. These findings suggest that pregnant blood is hypercoagulable. CIG did not change during pregnancy. In the fibrinolytic system, ELT was markedly diminished, PLg gradually elevated, alpha 2-PI and alpha 2-M did not change, and alpha 1-AT increased. These indicate that the fibrinolytic system is depressed on the whole.