Related Experiment Video
Updated: Aug 21, 2026

11:02
Methods for Experimental Manipulations after Optic Nerve Transection in the Mammalian CNS
Published on: May 12, 2011
Direct demonstration of transsynaptic degeneration in the human visual system: a comparison of retrograde and
Journal of Neurology, Neurosurgery, and Psychiatry
|February 1, 1982
Abstract:
Transneuronal degeneration of retinal ganglion cells was directly demonstrated in a patient who had unilateral removal of the striate cortex forty years prior to necropsy. For comparison, another case is presented showing anterograde transneuronal atrophy forty years after enucleation of one eye.

