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Risks to children from computed tomographic scan premedication

A A Mitchell, C Louik, P Lacouture

    JAMA
    |May 7, 1982
    PubMed
    Summary
    This summary is machine-generated.

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    Serious adverse reactions, including life-threatening events, occurred in 13% of children receiving premedication for computed tomographic (CT) head scans. High doses or multiple medications increased reaction risk, especially in infants.

    Area of Science:

    • Pediatric pharmacology
    • Radiology and imaging

    Background:

    • Premedication is common for computed tomographic (CT) scans in children.
    • Adverse reactions to premedication can be serious, necessitating surveillance.

    Purpose of the Study:

    • To determine the rates and risk factors for adverse reactions in hospitalized children undergoing CT head scans.
    • To identify specific patient or medication factors associated with increased risk.

    Main Methods:

    • Intensive drug surveillance program monitored 106 hospitalized children.
    • Data collected on premedication drugs, dosages, and observed adverse events.
    • Statistical analysis to identify risk factors for reactions.

    Main Results:

    • 13% of patients experienced adverse reactions.

    Related Experiment Videos

  • Four life-threatening cardiorespiratory events occurred with narcotic premedication.
  • Higher doses (RR 5.2) and multiple medications (RR 3.7) elevated risk.
  • All severe reactions were in infants under 3 months; two with morphine sulfate.

    • Conclusions:

    • Physicians must consider the risks of premedication adverse reactions in pediatric CT scans.
    • Infants are particularly vulnerable to severe reactions, even with recommended doses.
    • Drug surveillance is crucial for understanding and mitigating risks in pediatric imaging.