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Sigmoidoscopy
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Related Experiment Video

Updated: Jun 29, 2026

Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
09:02

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Published on: July 31, 2016

Continuous propranolol infusion following abdominal surgery

H Smulyan, S E Weinberg, P J Howanitz

    JAMA
    |May 14, 1982
    PubMed
    Summary

    Continuous intravenous propranolol infusion effectively maintained therapeutic levels during surgery for heart disease patients, preventing complications and the propranolol withdrawal syndrome.

    Area of Science:

    • Cardiology
    • Pharmacology
    • Surgical Medicine

    Background:

    • Long-term propranolol hydrochloride therapy is common for heart disease.
    • Surgical procedures in these patients pose risks related to beta-blockade withdrawal.

    Purpose of the Study:

    • To evaluate the safety and efficacy of continuous intravenous propranolol infusion during abdominal surgery.
    • To determine if this method prevents perioperative complications and propranolol withdrawal syndrome.

    Main Methods:

    • Thirteen patients on long-term propranolol therapy underwent 15 abdominal surgeries.
    • Propranolol was administered via continuous intravenous infusion postoperatively.
    • Serum propranolol concentrations were monitored frequently.

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    Main Results:

    • Therapeutic serum propranolol levels were achieved within a narrow dose range (averaging 3.0 mg/hr) in patients with normal hepatic and renal function.
    • All patients experienced postoperative courses free of complications attributed to beta-blockade.
    • Continuous infusion prevented the propranolol withdrawal syndrome.

    Conclusions:

    • Continuous intravenous propranolol infusion is a safe and effective method for maintaining therapeutic levels during surgical procedures.
    • This approach protects against perioperative sympathetic stimulation and prevents propranolol withdrawal syndrome.
    • It may be beneficial in other critical conditions where oral therapy is contraindicated.