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Related Experiment Videos

Urinary hydroxyproline excretion in acromegaly

J Halse, J O Gordeladze

    Acta Endocrinologica
    |November 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Acromegaly patients show daily fluctuations in urinary hydroxyproline excretion, peaking at night. Fasting growth hormone (GH) levels correlate with hydroxyproline excretion, suggesting a simplified assay for disease activity.

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    Area of Science:

    • Endocrinology
    • Metabolic Research

    Background:

    • Acromegaly is a disorder caused by excess growth hormone (GH).
    • Urinary hydroxyproline is a marker of collagen metabolism.

    Purpose of the Study:

    • To investigate the circadian rhythm of urinary hydroxyproline excretion in acromegaly patients.
    • To explore the correlation between GH levels and hydroxyproline excretion.

    Main Methods:

    • Studied 8 acromegaly patients on a collagen-free diet.
    • Monitored urinary hydroxyproline excretion over 24 hours.
    • Measured fasting GH levels and bone collagen content.

    Main Results:

    • Urinary hydroxyproline exhibited a circadian rhythm, with higher excretion at night/early morning.

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  • Significant correlation found between fasting GH and 24-hour hydroxyproline excretion (Rs=0.74).
  • Significant correlation found between GH and fasting hydroxyproline:creatinine ratios (Rs=0.76).

    • Conclusions:

    • Circadian rhythm of hydroxyproline excretion is present in acromegaly.
    • Fasting GH levels correlate with hydroxyproline excretion, indicating disease activity.
    • A simplified hydroxyproline assay may aid in assessing acromegaly activity.