Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes of electrooculogram (EOG) in Parkinson's disease

S G Economou, C N Stefanis

    Acta Neurologica Scandinavica
    |July 1, 1978
    PubMed
    Summary

    Parkinsonian patients show lower electrooculography (EOG) ratios compared to controls. L-dopa treatment normalized these EOG ratios, suggesting metabolic changes in the pigment epithelium are linked to Parkinson's disease.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Attitudes of psychology students to depression and its treatment: Implications for clinical practice.

    Psychiatrike = Psychiatriki·2017
    Same author

    Bipolar disorder and self-stigma: A comparison with schizophrenia.

    Journal of affective disorders·2015
    Same author

    Compulsory hospitalisation and optimal mental health care: A European perspective and the example of Greece.

    Psychiatrike = Psychiatriki·2012
    Same author

    [Social Distance Scale: Greek adaptation and psychometric properties].

    Psychiatrike = Psychiatriki·2011
    Same author

    Schizophrenia-related RGS4 gene variations specifically disrupt prefrontal control of saccadic eye movements.

    Psychological medicine·2011
    Same author

    Fighting psychiatric stigma in the classroom: the impact of an educational intervention on secondary school students' attitudes to schizophrenia.

    The International journal of social psychiatry·2011

    Area of Science:

    • Neuroscience
    • Ophthalmology
    • Biochemistry

    Background:

    • Parkinson's disease (PD) is a neurodegenerative disorder affecting motor function.
    • Electrooculography (EOG) measures eye movements and can reflect retinal pigment epithelium (RPE) function.
    • Previous research suggests potential ocular abnormalities in PD patients.

    Purpose of the Study:

    • To investigate electrooculographic (EOG) differences between Parkinsonian patients and healthy controls.
    • To assess the effect of L-dopa treatment on EOG findings in Parkinson's disease.
    • To explore the association between PD and metabolic changes in the RPE.

    Main Methods:

    • Comparison of EOG ratios in 20 Parkinsonian patients and 20 control subjects.
    • Evaluation of EOG findings before and after L-dopa treatment in PD patients.

    Main Results:

    • Parkinsonian patients exhibited significantly lower mean EOG ratios than controls.
    • L-dopa treatment led to the restoration of EOG ratios to levels observed in control subjects.
    • These findings indicate a functional alteration in the RPE of PD patients.

    Conclusions:

    • Electrooculography reveals distinct abnormalities in Parkinson's disease.
    • L-dopa therapy appears to improve RPE function in PD patients.
    • The results suggest a link between Parkinson's disease pathophysiology and metabolic alterations within the RPE's melanin-containing cells.

    Related Experiment Videos