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Related Experiment Videos

Decreasing immunogenicity of developing schistosome larvae

A Sher, D Benno

    Parasite Immunology
    |March 1, 1982
    PubMed
    Summary
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    Irradiated Schistosoma mansoni cercariae and skin-stage larvae induced significant protective immunity in mice. Lung-stage larvae were least immunogenic, suggesting a loss of immune recognition during parasite maturation.

    Area of Science:

    • Parasitology
    • Immunology
    • Infectious Diseases

    Background:

    • Schistosoma mansoni is a parasitic flatworm causing schistosomiasis.
    • Understanding the immunogenicity of different larval stages is crucial for vaccine development.

    Purpose of the Study:

    • To evaluate the immunogenicity of gamma-irradiated Schistosoma mansoni cercariae, skin-stage schistosomula, and lung-stage schistosomula.
    • To determine the protective immunity induced by these stages against cercarial challenge in mice.

    Main Methods:

    • Schistosoma mansoni larval stages (cercariae, skin-stage, lung-stage) were attenuated using gamma irradiation.
    • Immunization of C57Bl/6J mice with attenuated larvae via percutaneous, intramuscular, or intravenous routes.
    • Assessment of protective immunity through challenge with cercariae.

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  • Comparison of anti-skin stage schistosomular antibody responses.

    • Main Results:

    • Intramuscular or percutaneous administration of cercariae induced the highest levels of protective immunity.
    • Skin-stage schistosomula induced less protection, and lung-stage schistosomula were the least immunogenic.
    • Antibody responses correlated with protection, with no antibodies recognizing lung-stage schistosomula.

    Conclusions:

    • Schistosome larvae undergo a significant loss of immunogenicity as they mature from cercariae to lung-stage larvae.
    • This developmental change in immunogenicity may contribute to immune evasion in infected hosts.
    • Targeting earlier larval stages may be more effective for inducing protective immunity against schistosomiasis.