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Pleural effusion disease in rabbits. Histopathological observations
Acta Pathologica Et Microbiologica Scandinavica. Section A, Pathology
|May 1, 1978
Summary
Pleural effusion disease (PED) in rabbits causes minimal light microscopical changes, primarily affecting lymphoid tissues. Fatal infections show splenic white pulp reduction and thymus/lymph node degeneration.
Area of Science:
- Veterinary Pathology
- Infectious Diseases
- Rabbit Models
Background:
- Pleural effusion disease (PED) is a generalized infection in laboratory rabbits.
- The causative agent of PED is unidentified, but suspected to be viral.
Purpose of the Study:
- To investigate the histopathological response of laboratory rabbits experimentally infected with the agent causing PED.
- To characterize the light microscopical changes associated with PED infection in rabbits.
Main Methods:
- Experimental infection of 17 laboratory rabbits with the PED agent.
- Light microscopy examination of tissues from infected rabbits.
Main Results:
- Minimal light microscopical changes observed overall.
- Consistent alterations noted in lymphoid tissues.
- Fatal infections: reduced splenic white pulp, focal degenerative changes in thymus and lymph nodes, possible kidney glomerular changes.
- Surviving animals: transient myocardial and hepatic lesions, followed by proliferative changes in spleen, lymph nodes, lung, and kidneys post-recovery.
Conclusions:
- The study documented histopathological findings in rabbits with PED.
- Results did not elucidate the etiology or pathogenesis of PED infection.