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Prophylaxis of early post operative deep venous thrombosis by monitored heparin infusion
Increases in whole blood coagulability in patient undergoing abdominal surgery have been measured with the thrombelastograph. A continuous, low dose intravenous infusion of heparin has been administered in the operative period in an attempt to control these coagulability increases without increasing the risk of haemorrhage. A preliminary sub-cutaneous dose of heparin followed by a continuous infusion throughout the operation and for two hours afterwards effectively prevented the expected coagulability increase and resulted in reduction of early deep venous thrombosis incidence from 9/20 in controls to 1/19 in treated patients (p less than 0.05).
Increases in whole blood coagulability in patient undergoing abdominal surgery have been measured with the thrombelastograph. A continuous, low dose intravenous infusion of heparin has been administered in the operative period in an attempt to control these coagulability increases without increasing the risk of haemorrhage. A preliminary sub-cutaneous dose of heparin followed by a continuous infusion throughout the operation and for two hours afterwards effectively prevented the expected coagulability increase and resulted in reduction of early deep venous thrombosis incidence from 9/20 in controls to 1/19 in treated patients (p less than 0.05).