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Changes in quantitative norepinephrine levels in delayed pig flank flaps

C Cutting, R Bumsted, J Bardach

    Plastic and Reconstructive Surgery
    |April 1, 1982
    PubMed
    Summary
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    Tissue norepinephrine levels in pig flank flaps decreased initially after delay but recovered, suggesting preserved adrenergic innervation. This indicates adrenergic denervation is unlikely to explain the delay phenomenon in this model.

    Area of Science:

    • Plastic Surgery
    • Neuroscience
    • Tissue Engineering

    Background:

    • The delay phenomenon in flap surgery is a critical area of research.
    • Understanding the role of adrenergic innervation in flap survival is essential.
    • Previous studies on adrenergic denervation in flap models have yielded varied results.

    Purpose of the Study:

    • To quantitatively assess norepinephrine concentrations in bipedicle delayed pig flank flaps.
    • To investigate the role of adrenergic innervation in the delay phenomenon.
    • To determine factors influencing adrenergic denervation in flaps.

    Main Methods:

    • Serial quantitative norepinephrine assays were performed on pig flank flaps.
    • Tissue samples were analyzed to measure norepinephrine concentrations over time.

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  • Flap survival and adrenergic innervation were correlated.

    • Main Results:

    • Norepinephrine concentration significantly decreased after 24 hours post-delay.
    • Norepinephrine levels gradually returned to normal by 10 days.
    • The findings suggest significant preservation of adrenergic innervation in pig flank flaps.

    Conclusions:

    • Adrenergic denervation is unlikely to be the primary explanation for the delay phenomenon in this pig flank flap model.
    • Flap survival and the effectiveness of adrenergic blocking agents depend on the flap's anatomical relationship to cutaneous adrenergic neural anatomy.
    • The degree of adrenergic denervation is influenced by flap design and underlying neural anatomy.