Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

HLA and alcoholic cirrhosis

B D Tait, I R Mackay

Tissue Antigens

|January 1, 1982

Summary

Human leukocyte antigen (HLA) profiles differ between alcoholic cirrhosis and chronic active hepatitis (CAH). These immunogenetic differences suggest distinct predispositions to these liver diseases, impacting future research and treatment strategies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Rapid screening for the detection of HLA-B57 and HLA-B58 in prevention of drug hypersensitivity.

Tissue antigens·2011

Same author

Solid phase HLA antibody detection technology--challenges in interpretation.

Tissue antigens·2010

Same author

HLA-DRB1 associations with disease susceptibility and clinical course in Australians with multiple sclerosis.

Tissue antigens·2009

Same author

Replication of KIAA0350, IL2RA, RPL5 and CD58 as multiple sclerosis susceptibility genes in Australians.

Genes and immunity·2008

Same author

Immunodominance hierarchies and gender bias in direct T(CD8)-cell alloreactivity.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2007

Same author

SNP mapping and candidate gene sequencing in the class I region of the HLA complex: searching for multiple sclerosis susceptibility genes in Tasmanians.

Tissue antigens·2007

Area of Science:

Immunogenetics
Hepatology
Clinical Medicine

Background:

Alcoholic cirrhosis and autoimmune-type chronic active hepatitis (CAH) are distinct liver diseases.
Understanding the genetic predisposition to these conditions is crucial for diagnosis and treatment.
Human leukocyte antigen (HLA) genes play a significant role in immune responses and disease susceptibility.

Purpose of the Study:

To investigate the association of specific HLA-DR antigens with alcoholic cirrhosis.
To compare the HLA-DR profiles of patients with alcoholic cirrhosis, normal subjects, and patients with CAH.
To explore potential immunogenetic differences underlying the pathogenesis of alcoholic cirrhosis and CAH.

Main Methods:

Human leukocyte antigen (HLA) typing was performed on patients with alcoholic cirrhosis, normal subjects, and patients with CAH.
The frequencies of specific HLA-DR antigens (HLA-DR2 and HLA-DR3) were analyzed in each group.
Statistical comparison of antigen frequencies between the groups was conducted.

Main Results:

The frequency of HLA-DR2 was significantly higher in patients with alcoholic cirrhosis (47.4%) compared to normal subjects (26.1%) and CAH patients (14.0%).
The frequency of HLA-DR3 was lower in alcoholic cirrhosis patients (24.6%) compared to normal subjects (31.9%) and markedly lower than in CAH patients (74.4%).
Distinct HLA-DR profiles were observed between alcoholic cirrhosis and CAH, indicating different genetic associations.

Conclusions:

The study highlights significant differences in HLA-DR antigen frequencies between alcoholic cirrhosis and CAH.
These findings suggest distinct immunogenetic factors contribute to the predisposition of these two liver diseases.
The observed HLA-DR profiles may aid in differentiating between alcoholic cirrhosis and CAH and understanding their underlying mechanisms.

Related Experiment Videos