Cytosine arabinoside bladder instillation therapy for bladder tumors

Bladder instillation of cytosine arabinoside (CA), 400 mg in 20 ml sterilized distilled water, was performed in 30 cases of bladder tumors. The instillation was done everyday to inpatients or 3 times a week to outpatients, for a total of 20 procedures. The total effective rate was 33%. Although the effectiveness of CA bladder instillation was less than that of mitomycin C and adriamycin, the combination of CA and these drugs might be advisable. Neither general nor local side effect was observed.