Significance of sustained gastric hypersecretion by the emulsified histamine solution

Experimental production of gastric and duodenal ulcers was investigated in dogs by administration of histamine emulsified in Freund's incomplete adjuvant. Acid secretory responses were also checked. The results are as follows: Intramuscular administration of 10 mg/day of the emulsified histamine solution caused sustained gastric hypersecretion due to gradual liberation of histamine but produced no apparent side effects. However, neither gastric nor duodenal ulcer was observed within 2 months with the dosage of 10 mg/day. These results suggest that intramuscular administration of the dosage of 10 mg/day within 2 months would be a valuable means to elucidate the pathogenesis of ulcer under the sustained gastric hypersecretion.