[Cerebrospinal fluid immunoglobulins in patients with acute tick-borne encephalitis]

Data characterizing the quantitative parameters and the spectrum of basic non-specific and specific immunoglobulins (IgA, IgG, IgM) in the cerebrospinal fluid (CSF) of patients with acute tick-borne encephalitis are presented. Statistically significant differences in the intensity and character of the changes in the protein constituents of the CSF were revealed in patients with the subclinical form and forms accompanied with the brain affection. On the basis of evaluating the cerebral microcirculation in the patients with tick-borne encephalitis, and determining the correlation between the content of immunoglobulins in the CSF and the serum an idea is suggested that of a certain significance for the rise of the immunoglobulin levels is (in addition to their local synthesis in the CNS) the phenomenon of protein filtration through the damaged hematoencephalic barrier in the acute period of the infection.