Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chronic relapsing polyneuritis. A light- and electron-microscopic study

N Rizzuto, G Moretto, S Monaco

    Acta Neuropathologica
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Microwave ablation for large benign thyroid nodules: a proposal for a new approach: "the fluid-motion technique".

    Updates in surgery·2023
    Same author

    Reduction of the emergency activity, during the Covid 19 Italian lockdown, what's the lesson to learn?

    Health policy (Amsterdam, Netherlands)·2021
    Same author

    Cognitive load in 3d and 2d minimally invasive colorectal surgery.

    Surgical endoscopy·2020
    Same author

    Hub-and-spoke stroke network in the Veneto region: a retrospective study investigating the effectiveness of the stroke pathway and trends over time.

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2017
    Same author

    Use of biological mesh in trans-anal treatment for recurrent recto-urethral fistula.

    International urology and nephrology·2017
    Same author

    Seizures and Brain Arterovenous Malformation: A Surgical Series.

    Acta neurochirurgica. Supplement·2016
    Same journal

    Mutation-specific neuropathologic signatures in MAPT-associated frontotemporal lobar degeneration.

    Acta neuropathologica·2026
    Same journal

    Molecular changes during AT/RT progression associated with epithelial-mesenchymal transition and extracellular matrix changes.

    Acta neuropathologica·2026
    Same journal

    Prion-like transmission and propagation of human β-amyloid to the bank vole rodent model.

    Acta neuropathologica·2026
    Same journal

    Inhibition of tRNA fragments dysregulated in human mTLE exacerbates pathology and seizure activity.

    Acta neuropathologica·2026
    Same journal

    VMA21 deficiency leads to autophagic dysregulation and altered vesicle trafficking in X-linked myopathy with excessive autophagy.

    Acta neuropathologica·2026
    Same journal

    Donor-specific pathological features associate with genetic background, lesion type distribution, and clinical heterogeneity in multiple sclerosis.

    Acta neuropathologica·2026
    See all related articles

    Chronic relapsing polyneuritis involves ongoing nerve damage, not just relapses. This continuous demyelination and remyelination leads to progressive motor deterioration and nerve changes.

    Area of Science:

    • Neurology
    • Pathology

    Background:

    • Chronic relapsing polyneuritis (CR P) is characterized by recurrent episodes of nerve inflammation and damage.
    • Patients often experience partial recovery after attacks, but a trend towards increasing disability is observed.

    Observation:

    • Two patients with CR P exhibited progressive motor deterioration over time.
    • Peripheral nerve biopsies in advanced stages revealed significant loss of myelinated fibers.
    • Microscopic examination showed evidence of repeated demyelination and remyelination, forming onion bulb complexes.

    Findings:

    • The study identified ongoing nerve damage activity in CR P, even between clinical relapses.
    • Simultaneous presence of demyelinated axons, remyelinating fibers, and macrophage-associated remyelinated fibers was noted.

    Related Experiment Videos

  • The continuous demyelination-remyelination cycle impedes the clearance of excess Schwann cells, leading to nerve fascicle hypertrophy.

    • Implications:

    • CR P involves a persistent pathological process beyond apparent clinical relapses.
    • Understanding this ongoing nerve damage is crucial for developing effective therapeutic strategies.
    • The findings highlight the complex interplay between demyelination, remyelination, and Schwann cell dynamics in chronic neuropathies.