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Related Concept Videos

Storage01:23

Storage

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A schema is a mental framework that helps individuals organize and interpret information. Schemata, formed from previous experiences, influence how we process new information: how we encode it, the inferences we make, and how we retrieve it. For instance, a schema for what a typical classroom looks like might include desks, a teacher's desk, a whiteboard, and students in such an environment. This expectation helps us quickly understand and navigate new classrooms without needing to analyze...
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ATP Energy Storage and Release01:31

ATP Energy Storage and Release

14.7K
ATP is a highly unstable molecule. Unless quickly used to perform work, ATP spontaneously dissociates into ADP and inorganic phosphate (Pi), and the free energy released during this process is lost as heat. The energy released by ATP hydrolysis is used to perform work inside the cell and depends on a strategy called energy coupling. Cells couple the exergonic reaction of ATP hydrolysis with endergonic reactions, allowing them to proceed.
One example of energy coupling using ATP involves a...
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Sugars as Energy Storage Molecules01:10

Sugars as Energy Storage Molecules

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Sugar (a simple carbohydrate) metabolism (chemical reactions) is a classic example of the many cellular processes that use and produce energy. Living things consume sugar as a major energy source because sugar molecules have considerable energy stored within their bonds. Consumed carbohydrates have their origins in photosynthesizing organisms like plants. During photosynthesis, plants use the energy of sunlight to convert carbon dioxide gas into sugar molecules, like glucose. Because this...
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Fats as Energy Storage Molecules01:06

Fats as Energy Storage Molecules

27.1K
Triglycerides are a form of long-term energy storage molecules. They are made of glycerol and three fatty acids. To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. This process, called lipolysis, takes place in the cytoplasm. The resulting fatty acids are oxidized by β-oxidation into acetyl-CoA, which is used by the Krebs cycle. The glycerol that is released from triglycerides after lipolysis...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Immunodeficiency Diseases01:25

Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
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Related Experiment Video

Updated: Feb 14, 2026

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A suspected new canine storage disease

W J Hartley, P J Canfield, T M Donnelly

    Acta Neuropathologica
    |January 1, 1982
    PubMed
    Summary

    This study details a new storage disorder in English Springer Spaniels, characterized by progressive neurological signs and distinctive cellular changes in nerves and organs. The findings suggest a potential oligosaccharide storage, offering insights into canine neurodegenerative diseases.

    Area of Science:

    • Veterinary Neurology
    • Canine Pathology
    • Lysosomal Storage Disorders

    Background:

    • Progressive neurological disorders can significantly impact canine health and welfare.
    • Identifying novel storage diseases is crucial for accurate diagnosis and potential therapeutic strategies.

    Purpose of the Study:

    • To describe three cases of a likely new storage disorder in English Springer Spaniels.
    • To characterize the neuropathological and systemic features of this novel canine disease.

    Main Methods:

    • Clinical examination of affected dogs.
    • Light and electron microscopy of peripheral nerves, central nervous system, and other organs.
    • Histopathological analysis of tissue samples.

    Main Results:

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    • Affected dogs exhibited progressive neurological signs and enlarged nerves.
    • Histopathology revealed endoneurial fibrosis, foamy phagocytes, neuronal cytoplasmic vacuolation, myelin loss, and astrocytosis.
    • Ultrastructural analysis showed membrane-bound vacuoles containing amorphous material or lamellar structures.
    • Similar changes were observed in renal tubules, pancreatic parenchyma, lymph nodes, and lungs.

    Conclusions:

    • The findings suggest a new form of storage disorder in English Springer Spaniels.
    • The stored material is hypothesized to be an oligosaccharide.
    • This condition represents a significant finding in canine neurodegenerative and metabolic diseases.