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High density lipoprotein composition versus heredity for acute myocardial infarction in middle-aged males
Insights
Low high-density lipoprotein (HDL) cholesterol in men is linked to higher risk of fathers having acute myocardial infarction (AMI). Higher apolipoprotein AI (Apo AI) also showed a weaker association with paternal AMI.
Area of Science:
- Cardiovascular Health
- Lipid Metabolism
- Genetic Epidemiology
Background:
- High-density lipoprotein (HDL) cholesterol and apolipoprotein AI (Apo AI) are key lipid parameters.
- Dyslipidemia, including low HDL, is a risk factor for cardiovascular disease.
Purpose of the Study:
- To investigate the relationship between HDL cholesterol, Apo AI levels, and the risk of acute myocardial infarction (AMI) in fathers.
Main Methods:
- Serum lipid profiles (HDL cholesterol, triglycerides, Apo AI) were measured in 299 middle-aged men.
- Statistical analysis was used to assess correlations and familial AMI history.
Main Results:
- A significant negative correlation was observed between HDL cholesterol and serum triglyceride levels.
- Low HDL cholesterol in sons was significantly associated with a history of paternal AMI.
- A weaker association was found between high Apo AI levels in sons and paternal AMI.
Conclusions:
- Low HDL cholesterol in men may serve as a potential indicator for increased risk of cardiovascular events in their fathers.
- Paternal AMI history shows a stronger link with son's low HDL cholesterol than with son's high Apo AI levels.
Abstract:
The levels of high density lipoprotein (HDL) cholesterol and apolipoprotein AI (Apo AI) were determined in 299 men, 48 years of age. We found a significant negative correlation between HDL cholesterol and serum triglyceride concentrations and a significant correlation between serum triglyceride concentration and the Apo AI/HDL cholesterol ratio. A history of acute myocardial infarction (AMI) was significantly more common than expected among the fathers of men with a low HDL cholesterol level. We also found a relationship between AMI among fathers and high Apo AI level in sons, although this relationship was not as strong as that between AMI among fathers and low HDL cholesterol in sons. No significant relationship was found between AMI among mothers and HDL cholesterol or Apo AI in sons.