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Bone mineral content in myelomatosis
Acta Medica Scandinavica
|January 1, 1982
Summary
Patients with multiple myeloma (myelomatosis) did not show reduced bone mineral content (BMC) compared to healthy individuals. This suggests myelomatosis does not cause generalized osteoporosis, even in patients with X-ray diagnosed osteoporosis.
Area of Science:
- Bone Metabolism and Disease
- Oncology
- Radiology
Background:
- Multiple myeloma (myelomatosis) is a cancer of plasma cells.
- Osteoporosis is characterized by reduced bone mineral density and increased fracture risk.
- The relationship between myelomatosis and generalized osteoporosis requires further elucidation.
Purpose of the Study:
- To assess bone mineral content (BMC) in patients with myelomatosis.
- To compare BMC in myelomatosis patients with a healthy population.
- To investigate the correlation between disease duration, osteoporosis diagnosis, and BMC in myelomatosis.
Main Methods:
- Photon absorptiometry was used to measure BMC in the forearms of 28 myelomatosis patients.
- Patients' BMC was compared to an age- and sex-matched normal population.
- Routine X-rays were used to identify osteoporosis in a subset of patients.
Main Results:
- No significant difference in BMC was found between myelomatosis patients and the control group.
- BMC did not decrease significantly with the duration of myelomatosis.
- Patients with X-ray diagnosed osteoporosis were older but had comparable BMC to those without osteoporosis.
Conclusions:
- Myelomatosis does not appear to cause generalized osteoporosis.
- Reduced bone mineral content is not a characteristic feature of myelomatosis, irrespective of osteoporosis diagnosis on X-ray.