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Exercise-induced changes in common laboratory tests

J B Priest, T O Oei, W R Moorehead

    American Journal of Clinical Pathology
    |March 1, 1982
    PubMed
    Summary
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    Heavy exercise, like a mini-marathon, significantly elevates serum markers including potassium (K+), BUN, creatinine, CK, LDH, and leukocyte counts in male runners. These post-exercise elevations are common and depend on exercise intensity and timing of tests.

    Area of Science:

    • Sports Medicine
    • Clinical Biochemistry
    • Hematology

    Background:

    • Athletic performance can impact physiological markers.
    • Understanding post-exercise biochemical changes is crucial for interpreting clinical tests.

    Purpose of the Study:

    • To examine the immediate effects of a 13-mile run on serum biochemical and hematologic parameters in male runners.
    • To determine the prevalence of abnormal values post-exercise.

    Main Methods:

    • Blood samples were collected from 23- to 47-year-old white male runners before and after a 13-mile mini-marathon.
    • Nineteen serum biochemical and hematologic parameters were analyzed.
    • Paired Student t-tests were used to assess significant changes.

    Main Results:

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    • Significant increases were observed in mean values of K+, BUN, creatinine, CK, LDH, AST (SGOT), alkaline phosphatase, bilirubin, uric acid, and leukocyte counts post-exercise.
    • Post-exertional values above normal limits were frequent for CK (93%), LDH (86%), and leukocyte counts (71%).
    • Elevated BUN, creatinine, and uric acid were also noted post-exercise.

    Conclusions:

    • Abnormally high values for several serum markers are expected in individuals after strenuous exercise.
    • The extent of these abnormalities is influenced by exercise duration, intensity, and the time between exertion and testing.
    • These findings are important for clinicians interpreting lab results in athletes.