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Progressive cutaneous protothecosis

F R Venezio, E Lavoo, J E Williams

    American Journal of Clinical Pathology
    |April 1, 1982
    PubMed
    Summary
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    A woman with severe cutaneous protothecosis had a defect in polymorphonuclear leukocytes (PMN) killing ability. Treatment with antifungals led to lesion resolution and negative cultures, indicating successful therapy.

    Area of Science:

    • Medical Mycology
    • Immunology
    • Dermatology

    Background:

    • Cutaneous protothecosis is a rare infection caused by Prototheca species, often affecting immunocompromised individuals.
    • Diagnosis typically involves skin biopsy and microbial culture.
    • Understanding host immune responses is crucial for managing this challenging infection.

    Observation:

    • A 34-year-old woman presented with severe, progressive cutaneous protothecosis.
    • Skin biopsy and culture confirmed the diagnosis.
    • Analysis revealed a persistent defect in polymorphonuclear leukocyte (PMN) function, specifically impaired killing of the Prototheca organism.

    Findings:

    • The patient demonstrated specific IgG and IgE antibodies against the pathogen.
    • Serum complement and immunoglobulin levels were normal or elevated.

    Related Experiment Videos

  • Cellular immunity appeared intact, with lymphocytes responding to mitogens and no anergy observed.

    • Implications:

    • This case highlights a specific immune defect (impaired PMN killing) in cutaneous protothecosis.
    • Successful treatment with amphotericin B and tetracycline suggests effective therapeutic options.
    • Further research into immune defects may guide personalized treatment strategies for protothecosis.