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Disseminated ulcerations in allergic eosinophilic gastroenterocolitis
The American Journal of Gastroenterology
|April 1, 1982
Summary
Allergic eosinophilic gastroenterocolitis in an infant caused severe gastrointestinal issues. Corticosteroid treatment led to complete clinical and histological remission, demonstrating treatment efficacy.
Area of Science:
- Pediatric Gastroenterology
- Allergology
- Immunology
Background:
- Eosinophilic gastroenterocolitis (EGID) is a rare gastrointestinal disorder.
- It is characterized by eosinophilic infiltration of the gastrointestinal tract.
- Allergic triggers are implicated in the pathogenesis of EGID.
Observation:
- An infant presented with vomiting, diarrhea, gastrointestinal bleeding, and failure to thrive.
- Laboratory findings included anemia, hypoproteinemia, and peripheral eosinophilia.
- Endoscopy revealed widespread mucosal ulcerations in the stomach, small intestine, and colon.
Findings:
- Histological examination confirmed eosinophilic infiltration of the mucosa.
- Increased mucosal IgE plasma cells and activated intraepithelial lymphocytes were observed.
- These findings are characteristic of allergic eosinophilic gastroenterocolitis.
Implications:
- Corticosteroid therapy resulted in both clinical improvement and histological remission.
- This case highlights the effectiveness of corticosteroids in managing severe EGID in infants.
- Early diagnosis and treatment are crucial for favorable outcomes in pediatric EGID.