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Comparison of ruminant anthelmintics, using multiple dose administration

D K Hass, E L Holloway, L J Brown

    American Journal of Veterinary Research
    |March 1, 1982
    PubMed
    Summary
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    Fenbendazole and oxfendazole effectively controlled parasitism in lambs at 5 mg/kg feed. Other anthelmintics showed varying efficacy, with some ineffective at higher doses.

    Area of Science:

    • Veterinary Medicine
    • Parasitology
    • Animal Science

    Background:

    • Parasitic infections pose significant health and economic challenges in ruminant livestock.
    • Effective anthelmintic treatments are crucial for maintaining animal welfare and productivity in sheep farming.

    Purpose of the Study:

    • To evaluate the efficacy of eleven different ruminant anthelmintics against natural parasitic infections in lambs.
    • To determine optimal dosage and administration routes (medicated feed vs. oral dose) for effective parasite control.

    Main Methods:

    • Eleven anthelmintics were administered to lambs over 30 days via medicated feed or multiple oral doses.
    • Efficacy was assessed based on the control of clinical parasitism and parasite load.

    Main Results:

    Related Experiment Videos

    • Fenbendazole and oxfendazole demonstrated over 90% efficacy at 5 mg/kg feed.
    • Parbendazole and albendazole were effective at 1 mg/kg body weight (oral) and 10 mg/kg feed, respectively.
    • Levamisole, mebendazole, and oxibendazole were ineffective at tested dosages.

    Conclusions:

    • Fenbendazole and oxfendazole are highly effective anthelmintics for lambs at specific feeding levels.
    • Dosage and administration method significantly influence anthelmintic efficacy in ruminants.
    • Further research may be needed to optimize treatments for less effective compounds.