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Acute renal failure--current concepts

E J Lee

    Annals of the Academy of Medicine, Singapore
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Acute renal failure (ARF) mortality has decreased due to better understanding and treatments like dialysis. The causes of ARF are evolving, with nephrotoxins playing a greater role.

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    Area of Science:

    • Nephrology
    • Critical Care Medicine
    • Internal Medicine

    Background:

    • Historically, acute renal failure (ARF) in wartime casualties had high mortality rates.
    • Advances in understanding clinical manifestations and therapeutic interventions have significantly improved outcomes.
    • The landscape of ARF is changing, with increasing recognition of nephrotoxins' role.

    Purpose of the Study:

    • To review the evolution of acute renal failure management and understanding.
    • To highlight changes in predisposing factors and clinical features of ARF.
    • To emphasize the growing importance of nephrotoxic agents in ARF.

    Main Methods:

    • Review of clinical manifestations and therapeutic techniques for ARF.
    • Analysis of historical data and contemporary observations in ARF.

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  • Identification of evolving etiological factors, including nephrotoxins.

    • Main Results:

    • Mortality from ARF in casualties has been substantially reduced.
    • Improved resuscitation, early dialysis, and maintaining high urine flow are key interventions.
    • Non-oliguric ARF is a recognized clinical entity, and nephrotoxic agents are increasingly implicated.

    Conclusions:

    • The management of acute renal failure has significantly advanced, leading to lower mortality.
    • Understanding the changing spectrum of ARF, including the impact of nephrotoxins, is crucial for effective treatment.
    • Continued research into the mechanisms of ARF is necessary despite therapeutic progress.