Related Experiment Videos
Pharmacokinetics of ceforanide
Antimicrobial Agents and Chemotherapy
|February 1, 1982
Summary
Ceforanide, a parenteral cephalosporin antibiotic, demonstrated linear pharmacokinetics across tested doses. This new antibiotic is 100% bioavailable intramuscularly with a half-life of 2.9 hours.
Area of Science:
- Pharmacology
- Antibiotic Research
- Clinical Pharmacokinetics
Background:
- Ceforanide is a novel parenteral cephalosporin antibiotic.
- Understanding its pharmacokinetic profile is crucial for effective therapeutic use.
Purpose of the Study:
- To evaluate the pharmacokinetics of ceforanide following intravenous and intramuscular administration.
- To determine dose proportionality, bioavailability, and elimination characteristics.
Main Methods:
- Healthy male volunteers received intravenous or intramuscular doses of ceforanide (250, 500, 1,000 mg).
- Serum drug concentrations were measured over time.
- Pharmacokinetic parameters including clearance, half-life, and bioavailability were calculated.
Main Results:
- Ceforanide exhibited linear pharmacokinetics within the studied dose range.
- Plasma clearance ranged from 2.2 to 2.5 L/h, with an estimated half-life of 2.9 hours.
- Intramuscular administration showed 100% bioavailability, with peak serum levels achieved at different concentrations compared to intravenous administration.
Conclusions:
- Ceforanide demonstrates predictable pharmacokinetic behavior, supporting its parenteral administration.
- The drug is fully bioavailable via intramuscular route and is primarily eliminated unchanged in the body.