Petroleum refinery wastewater induction of the hepatic mixed-function oxidase system in Pacific staghorn sculpin

Induction of hepatic microsomal cytochrome P450 and aldrin epoxidase was observed in the estuarine sculpin (Leptocottus armatus), following in vivo exposure to Class B petroleum refinery effluent from two West Coast refineries. The data demonstrate the presence and inducibility of the mixed-function oxidase system in Leptocottus armatus. Differences in the extent of mixed-function oxidase induction between the two effluents may be related to differences in wastewater chemistry.