Correlation of lithium effect on electroshock-induced seizure in rats with its concentration in brain and plasma

Effects of graded doses of lithium chloride (2.5, 5.0 and 7.5 mEq/kg, i.p.) on electroshock-induced seizure threshold, recovery time and concentration of lithium (Li) ion in plasma and brain tissue of albino rats, at different post injection intervals, were investigated. A significant decrease in seizure susceptibility corresponded with high Li ion concentration at 4 to 8 hr post injection period in the rat brain tissue.