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Muscle metabolism during exercise

J O Holloszy

    Archives of Physical Medicine and Rehabilitation
    |May 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Endurance exercise enhances skeletal muscle by increasing mitochondria and capillaries. This improves exercise capacity by promoting fat oxidation and reducing glucose utilization and lactate production.

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    Area of Science:

    • Exercise physiology
    • Skeletal muscle biology
    • Metabolic adaptation

    Background:

    • Endurance exercise leads to significant physiological adaptations in skeletal muscle.
    • Understanding these adaptations is key to comprehending enhanced work capacity.

    Purpose of the Study:

    • To examine the metabolic changes in skeletal muscle following endurance exercise.
    • To elucidate the role of these adaptations in increased work capacity.

    Main Methods:

    • The study focuses on the adaptive increases in mitochondrial content and respiratory capacity.
    • It also considers changes in myoglobin concentration and capillary number in skeletal muscle.

    Main Results:

    • Trained muscles show slower utilization of glycogen and glucose during submaximal exercise.

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  • Increased reliance on fat oxidation and reduced lactate production are observed in trained individuals.
  • These adaptations result in a smaller disturbance to homeostasis during exercise.

    • Conclusions:

    • Endurance exercise induces beneficial adaptations in skeletal muscle metabolism.
    • These adaptations significantly contribute to the enhanced work capacity observed with training.