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Hemodialysis therapy for psoriasis

K S Chugh, B Kumar, S K Pareek

    Artificial Organs
    |February 1, 1982
    PubMed
    Summary
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    Dialytic therapy, a form of dialysis, effectively treated extensive plaque psoriasis in most patients. Many experienced long-term remission of skin lesions, suggesting dialysis is a viable treatment option for psoriasis.

    Area of Science:

    • Nephrology
    • Dermatology
    • Internal Medicine

    Background:

    • Psoriasis is a chronic inflammatory skin condition.
    • Conventional treatments for extensive plaque psoriasis are often ineffective.
    • Dialytic therapy has not been widely explored for psoriasis treatment.

    Purpose of the Study:

    • To evaluate the efficacy of dialytic therapy in patients with treatment-resistant plaque psoriasis.
    • To assess the duration of remission and recurrence rates after dialytic therapy.

    Main Methods:

    • Twenty-five patients with extensive plaque psoriasis were included.
    • Twenty patients received twice-weekly, six-hour dialysis sessions using a Cuprophan membrane dialyzer.
    • Five patients served as controls, receiving sham dialysis, ultrafiltration, or heparinization.

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    Main Results:

    • Eighteen of twenty dialyzed patients showed regression of psoriatic skin lesions.
    • Twelve patients remained in remission for 6 to 27 months post-treatment.
    • Ultrafiltration showed partial regression; sham dialysis and heparinization had no effect.

    Conclusions:

    • Dialytic therapy demonstrates a significant role in managing extensive plaque psoriasis.
    • Long-term remission is achievable for many patients undergoing dialysis.
    • Further research into the mechanisms of dialysis in psoriasis treatment is warranted.