Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Visual system abnormalities in patients with Parkinson's disease

M J Kupersmith, E Shakin, I M Siegel

    Archives of Neurology
    |May 1, 1982
    PubMed
    Summary

    Parkinson's disease (PD) patients show delayed visual evoked potentials (VEPs) and reduced contrast sensitivity. These visual impairments correlate with motor disability severity, suggesting potential central nervous system involvement rather than retinal issues.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    H3K9 methyltransferases and demethylases control lung tumor-propagating cells and lung cancer progression.

    Nature communications·2018
    Same author

    Role of vitamin A metabolism in IIH: Results from the idiopathic intracranial hypertension treatment trial.

    Journal of the neurological sciences·2016
    Same author

    Rapid light-induced potentials common to plant and animal tissues.

    Nature·2010
    Same author

    Occlusion of the internal carotid artery based on a simple tolerance test.

    Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences·2010
    Same author

    Vaginal wet mounts on asymptomatic adolescent females; are they beneficial?

    Journal of pediatric and adolescent gynecology·2008
    Same author

    Soluble receptor for advanced glycation end products in multiple sclerosis: a potential marker of disease severity.

    Multiple sclerosis (Houndmills, Basingstoke, England)·2008

    Area of Science:

    • Neuroscience
    • Ophthalmology
    • Neurology

    Background:

    • Parkinson's disease (PD) is a neurodegenerative disorder primarily affecting motor function.
    • Visual disturbances are increasingly recognized in PD patients, but their origin remains unclear.

    Purpose of the Study:

    • To investigate visual processing in normally sighted Parkinson's disease patients.
    • To determine the origin of visual pathway abnormalities in PD.

    Main Methods:

    • Visual evoked potentials (VEPs) using alternating gratings were recorded.
    • Contrast sensitivity was measured subjectively.
    • Electroretinography (ERG) was performed to assess retinal function.

    Main Results:

    Related Experiment Videos

  • Prolonged P100 wave latency in VEPs was observed in PD patients.
  • VEP latency delay correlated positively with motor disability severity.
  • Elevated contrast thresholds indicated reduced contrast sensitivity in PD patients.
  • ERG oscillatory potentials showed no specific retinal lesions.

    • Conclusions:

    • PD patients exhibit significant visual pathway abnormalities, including delayed VEPs and reduced contrast sensitivity.
    • These visual deficits are linked to the severity of motor symptoms in PD.
    • The findings suggest the visual abnormalities in PD are likely of central nervous system origin, not primarily retinal.