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Related Experiment Videos

Development and evaluation of a disposable device for performing simultaneous duplicate bleeding time determinations

S R Babson, A L Babson

    American Journal of Clinical Pathology
    |September 1, 1978
    PubMed
    Summary

    A new disposable device for measuring bleeding time offers standardized incisions. This device is simple, painless, and minimally traumatic, with reliable results in normal adults and after aspirin ingestion.

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    Area of Science:

    • Medical Devices
    • Hematology
    • Clinical Diagnostics

    Background:

    • Accurate measurement of bleeding time is crucial for diagnosing hemostatic disorders.
    • Existing methods for bleeding time assessment can be variable and invasive.

    Purpose of the Study:

    • To describe a novel disposable device for standardized bleeding time measurement.
    • To evaluate the device's reliability and performance in normal adults and after aspirin administration.

    Main Methods:

    • A disposable device creating two simultaneous standardized incisions was utilized.
    • Bleeding times were measured in 47 normal adults to establish reference ranges.
    • Duplicate measurements assessed intra-individual variability.
    • A double-blind crossover study in 20 adults evaluated the effect of aspirin (1g) on bleeding time.

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    Main Results:

    • The mean bleeding time in normal adults was 4.1 minutes (95% range: 2.2–7.0 min).
    • The device demonstrated good reproducibility with low standard deviations for duplicate (0.7 min) and day-to-day (0.9 min) measurements.
    • Aspirin ingestion significantly increased mean bleeding time from 3.7 to 6.2 minutes.

    Conclusions:

    • The disposable bleeding time device is simple to use, minimally invasive, and essentially painless.
    • The device provides reliable and reproducible bleeding time measurements.
    • It effectively detects changes in hemostasis, such as those induced by aspirin.