Possible functional coupling of hexose-6-phosphate dehydrogenase to microsomal electron transport system in rat...

Intrarenal distributions of cytosolic glucose-6-phosphate dehydrogenase, microsomal hexose-6-phosphate dehydrogenase, NADPH-cytochrome c reductase, mixed-function oxidases and cytochrome P-450, and effects of phenobarbital, methylcholanthrene, fasting, castration and sex hormones on the hepatic and renal enzyme activities were examined in an attempt to elucidate the as yet unknown function of hexose-6-phosphate dehydrogenase. The results show that there is a similarity between hexose-6-phosphate dehydrogenase, and NADPH-cytochrome c reductase with respect to the intrarenal distribution and the responsiveness to various treatments, thus suggesting functional coupling of hexose-6-phosphate dehydrogenase to microsomal electron transport system.