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The CAP Urine Chemistry Survey Program for 1977

G C Glenn

    American Journal of Clinical Pathology
    |September 1, 1978
    PubMed
    Summary

    The 1977 Urine Chemistry Survey revealed assay performance issues for amylase, 17-ketosteroids, and total protein. Glucose analysis also showed significant biases with specific methods.

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    Area of Science:

    • Clinical chemistry
    • Laboratory science
    • Urine analysis

    Background:

    • The Urine Chemistry Survey Program assesses laboratory performance.
    • In 1977, eleven analytes were evaluated, including electrolytes, enzymes, and metabolites.
    • Over 450 laboratories participated in the survey.

    Purpose of the Study:

    • To evaluate the performance of laboratory assays for common urine analytes.
    • To identify deficiencies and biases in analytical methods used in clinical laboratories.
    • To assess the precision and accuracy of urine chemistry testing.

    Main Methods:

    • Analysis of results from the 1977 Urine Chemistry Survey Program.
    • Evaluation of assay performance data submitted by participating laboratories.
    • Identification of analytes with reported deficiencies or significant performance shifts.

    Main Results:

    • Assay performance deficiencies were noted for amylase, 17-ketosteroids, and total protein.
    • Urea nitrogen analysis demonstrated sharp shifts in precision.
    • Glucose analysis using neocuproine and ferricyanide methods exhibited severe biases.

    Conclusions:

    • The 1977 survey highlighted areas needing improvement in urine chemistry assay performance.
    • Specific analytical methods for glucose and urea nitrogen require further investigation and refinement.
    • Consistent and accurate urine analyte measurement is critical for patient diagnosis and monitoring.

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