Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effects of rectification on synaptic efficacy

R W Joyner, M Westerfield

    Biophysical Journal
    |April 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Investigating postsynaptic membrane properties reveals how they shape synaptic potentials. Rectification effects significantly alter synaptic potential amplitude and duration, even at low voltages.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Affinity purification of in vivo assembled whirlin-associated protein complexes from the zebrafish retina.

    Journal of proteomics·2022
    Same author

    Zebrafish models of human eye and inner ear diseases.

    Methods in cell biology·2017
    Same author

    A scientist's guide for submitting data to ZFIN.

    Methods in cell biology·2016
    Same author

    Gene Ontology annotations and resources.

    Nucleic acids research·2012
    Same author

    Modality-specificity of sensory aging in vision and audition: evidence from event-related potentials.

    Brain research·2008
    Same author

    Insulin-like growth factor signaling regulates zebrafish embryonic growth and development by promoting cell survival and cell cycle progression.

    Cell death and differentiation·2007
    Same journal

    Enhanced-Sampling Simulations Reveal Distinct Intermediates in SARS-CoV-2 FSE Pseudoknot Interconversion.

    Biophysical journal·2026
    Same journal

    Structure-based simulations of the full Flock House virus capsid reveal pathways and energetics of an infection-critical peptide externalization event.

    Biophysical journal·2026
    Same journal

    Quantifying the Peripheral Surface Information Entropy from Conformational Ensembles of Globular Protein-Peptide Complexes.

    Biophysical journal·2026
    Same journal

    Anisotropic unbinding and location-dependent hovering of a kinesin motor head over microtubule.

    Biophysical journal·2026
    Same journal

    Kinesin-5/Cut7 C-terminal tail phosphorylation influence on motor regulation through multi-scale molecular modeling.

    Biophysical journal·2026
    Same journal

    Dynamic conformations of fluorophores on self-labeling protein tags.

    Biophysical journal·2026
    See all related articles

    Area of Science:

    • Computational Neuroscience
    • Cellular Electrophysiology

    Background:

    • Synaptic potentials are crucial for neural communication.
    • Understanding how postsynaptic membrane properties influence synaptic potential shape is essential.

    Purpose of the Study:

    • To investigate the impact of diverse postsynaptic membrane properties on synaptic potential morphology.
    • To analyze the effects of rectification on synaptic potentials under various conditions.

    Main Methods:

    • Numerical simulations of neuronal models with varying geometries (sphere, soma-dendritic tree).
    • Testing passive, Hodgkin-Huxley (HH), and modified passive membrane properties.
    • Evaluating synaptic potentials generated by fast and slow time-varying synaptic conductances.

    Main Results:

    Related Experiment Videos

    • Postsynaptic rectification effects were observed even for small synaptic potential amplitudes (as low as 1 mV).
    • The HH model exhibited increased peak amplitude (due to GNa) but decreased half-width and time integral (due to GK) compared to the passive model.
    • A simple analytical rectifier model replicated the GK-related effects observed in the HH model.

    Conclusions:

    • Postsynaptic membrane properties, particularly rectification, significantly shape synaptic potential dynamics.
    • The HH model's active properties introduce distinct modifications to synaptic potentials compared to passive models.
    • Rectifier models can effectively capture specific aspects of active membrane contributions to synaptic potentials.