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Related Experiment Videos

Adrenergic influences on the gallbladder emptying

F Lechin, B van der Dijs, A Bentolila

    The American Journal of Gastroenterology
    |June 1, 1978
    PubMed
    Summary
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    Dihydroergotamine (DHE) hinders gallbladder emptying stimulated by cholecystokinin (CCK). This alpha-adrenergic blocker caused organ relaxation and duodenal spasticity, impacting digestion.

    Area of Science:

    • Gastroenterology
    • Pharmacology

    Background:

    • Gallbladder emptying is regulated by cholecystokinin (CCK).
    • Alpha-adrenergic agents can influence gastrointestinal motility.

    Purpose of the Study:

    • To investigate the effect of dihydroergotamine (DHE) on CCK-stimulated gallbladder emptying.
    • To explore the role of alpha-adrenergic blockade in gallbladder function.

    Main Methods:

    • 70 volunteers underwent cholecystography with CCK stimulation (test meal or IV CCK).
    • DHE (1 mg) was administered intramuscularly 45 minutes before the second cholecystokinetic stimulus.
    • Gallbladder emptying was assessed via cholecystograms.

    Main Results:

    • DHE significantly counteracted gallbladder emptying induced by both endogenous and exogenous CCK.

    Related Experiment Videos

  • The inhibitory effect was more pronounced when DHE preceded a test meal compared to direct CCK injection.
  • Delayed gastric emptying and duodenal spasticity were suggested as contributing factors.

    • Conclusions:

    • Dihydroergotamine impairs CCK-mediated gallbladder contraction.
    • Alpha-adrenergic blockade may lead to gallbladder relaxation and duodenal dysfunction, affecting digestive processes.